Translational Medicine at Brigham & Women's Hospital: Stossel's Research Group
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Principal Investigators

Tom Stossel, Director

Professors
John Hartwig
David Kwiatkowski
Tom Stossel

Assistant Professors
Joseph Italiano
Karin Hoffmeister
Sandra Dabora

Instructors
Hervé Falet
Po-Shun Lee
Fumi Nakamura

Karin Hoffmeister, M.D.

Selected Papers

Wandall HH, Hoffmeister KM, Sørensen AL, Rumjantseva V, Clausen H, Hartwig JH, Slichter SJ. Galactosylation does not prevent the rapid clearance of long-term, 4°C-stored platelets. Blood. 2008 Mar 15;111(6):3249-56.

Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007 Mar;47(3):442-51.   

Josefsson EC, Gebhard HH, Stossel TP, Hartwig JH, Hoffmeister KM. The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets. J Biol Chem. 2005 May 6;280(18):18025-32.   

Hoffmeister KM, Josefsson EC, Isaac NA, Clausen H, Hartwig JH, Stossel TP. Glycosylation restores survival of chilled blood platelets. Science. 2003 Sep 12;301(5639):1531-4.   

Bergmeier W, Burger PC, Piffath CL, Hoffmeister KM, Hartwig JH, Nieswandt B, Wagner DD. Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Blood. 2003 Dec 1;102(12):4229-35.   

Gamulescu MA, Seifert K, Tingart M, Falet H, Hoffmeister KM. Platelet moesin interacts with PECAM-1 (CD31). Platelets. 2003 Jun;14(4):211-7.   

Italiano JE Jr, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA. Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15;101(12):4789-96.   

Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell. 2003 Jan 10;112(1):87-97.   

Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH. Mechanisms of cold-induced platelet actin assembly. J Biol Chem. 2001 Jul 6;276(27):24751-9.   







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