Joseph E. Italiano, Ph.D.

Selected Papers

Italiano, J.E., Lecine, P., Shivdasani, R.A., and J.H. Hartwig. 1999. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J. Cell Biol. 147:1299-1312.   

Lecine, P., Italiano, J.E., Kim, S., Villeval, J., and R.A. Shivdasani. 2000. The hematopoietic-specific B1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood. 96:1366-1373.   

Schwer, H.D., Lecine, P., Tiwari, S., Italiano, JE, Hartwig, J.H., and R.A. Shivdasani. 2001. A lineage-restricted and divergent B-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Current Biology 11:579-586

Falet, H, Hoffmeister, K.M., Neujahr, Italiano, J.E. Jr. Southwick, F.S., T.P. Stossel, and J.H. Hartwig. 2002. Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. PNAS. 99:16782-7.

Italiano JE, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister K, Andre P, Wagner DD, Shivdasani RA. 2003. Mechanisms and implications of platelet discoid shape. Blood. 101: 4789-4796.   

Barkalow, K., Italiano, J.E., Matsuoka, Y., Bennett, V., and J.H. Hartwig. 2003. a-Adducin disassociates from F-actin and spectrin during platelet activation. J. Cell Biol. 161: 557-570.   

Barkalow, K., Falet, H., Italiano, J.E., Azim, A.C., Van Vugt, A., Carpenter, C.L., Schreiber, A.D., and J.H. Hartwig. 2003. Role for phosphoinositide 3-kinase in FcgRIIA-induced platelet shape change. Am J Cell Physiol 285: C797-C805.

Tiwari, S., Italiano, J.E., Barral, D.C., Mules, E.H., Novak, E., Swank, R.T., Seabra, M.C., and R.A. Shivdasani. 2003. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood. 102:3970-3979.   

Schulze, H., Korpal, M., Bergmeier, W. Italiano, J.E., Wahl, S., and R.A. Shivdasani. 2004. Interactions between the megakaryocyte/platelet-specific B1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood. 104:3949-3957.   

Varo, N., Libby, P., Nuzzo, R., Italiano, J.E., Doria, A., and U Schonbeck. 2005. Elevated release of sCD40L from platelets of diabetic patients by thrombin, glucose and advanced glycation end products. Diabetes and Vascular Disease Research. 2:81-87.

Patel, S., Richardson, J, Schulze, H., Kahle, E., Galjart, N., Drabek, K.,. Shivdasani, R.A., Hartwig, J and J.E Italiano. 2005. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 106:4076-4085.   

Richardson, J. , Shivdasani, R.A., Boers, C., Hartwig, J., Hartwig, J and J.E. Italiano. 2005. Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 106:4066-4075.   

Patel, S., Hartwig, J., and J.E. Italiano. 2005. The biogenesis of platelets from megakaryocyte proplatelets. JCI. 115:3348-3354.

Junt, T, Schulze, H., Chen, Z, Massberg, S., George, T., Krueger, A., Wagner, DD.,Graf, T., Italiano, JE., Shivdasani, R., and U.H. von Andrian. 2007. Dynamic visualization of thrombopoiesis within bone marrow. Science 317:1767-1770.   

Cervi, d., Yip, TT, Bhattacharya, N., Podust, VN, Peterson, J, Abou-Slaybi, Naumov, G., Italiano, JE, Folkman, J, and G. Klement. 2008. Platelet-associated PF-4 as a biomarker of early tumor growth. Blood. 111:1201-1207.   

Italiano, J.E., Richardson, J.L., Patel-Hett, S., Battinelli, E., Zaslavsky, Short, S., Ryeom, S., Folkman, J, and GL. Klement. 2008. Angiogenesis is regulated by a novel mechanism: Pro- and anti-angiogenic proteins are organized into separate platelet a-granules and differentially released. Blood. 111:1227-1233.   

Sehrawat S, Cullere X, Patel S, Italiano JE, and TN Mayadas. 2008. Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. MBC. 19: 1261-1270.

Patel-Hett, S, Richardson J, Schulze H, Drabek K, Isaac N, Hoffmeister K, Shivdasani RA, Bulinski C, Galjart, Hartwig JH, and JE Italiano. 2008. Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. EPub Jan. 30, 2008.